In this article, the Cu nanoparticles were prepared on the p-isopropyl calix[6]arene-modified glassy carbon electrode by preconcentration of copper ions in open circuit potential and consecutive electrochemical reduction of them. P-isopropyl calix[6]arene was used as a template for synthesis of the Cu nanoparticles due to the ability of its cavities to trap the copper ions. Bimetallic Cu/Pt nanoparticles were also obtained by galvanic replacement of metallic Cu with Pt by simply immersing the electrode surface in a PtCl4 aqueous solution. The surface morphology of the Cu and Cu/Pt fabricated nanoparticles was investigated using scanning electron microscopy (SEM). Then, the electrochemical characteristics were analyzed through the cyclic voltammetry and electrochemical impedance spectroscopy techniques. The morphology analysis of the deposits using SEM reveals that the sizes and distribution of the nanoparticles were tuned using calix[6]arene matrix. Cu/Pt-coated glassy carbon electrode exhibited a promising activity for electrochemical oxidation of hydrogen peroxide (H2O2). The proposed modified electrode showed two linear ranges for H2O2 detection, 0.05–1.00 mM and 1.00–13.00 mM, and a detection limit equal to 0.01 mM (S/N = 3).
