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Fatemeh Elmi

Fatemeh Elmi

Academic rank: Associate Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Marine and Oceanic Sciences
Address:
Phone: 01135305124

Research

Title
Synchrotron FTIR microspectroscopy study of the diabetic rat skin wound healing with collagen+glycolipoprotein-90 treatment
Type
JournalPaper
Keywords
SR-μFTIR;Wound healing;ASC+G-90;Lipid peroxidation;Collagen
Year
2022
Journal VIBRATIONAL SPECTROSCOPY
DOI
Researchers Maryam Mitra Elmi ، Fatemeh Elmi ، farideh feizi

Abstract

Impaired wound healing in diabetic foot ulceration is one of the severe challenges in diabetic patients, which profoundly affects their quality of life. Today, applying a novel and non-invasive method to promote wound healing in diabetic patients is of considerable interest. In this study, we aimed to load acid-soluble collagen (ASC) extracted from fish scale and the earthworm glycolipoprotein (G-90), ASC + G-90, and test it on injured diabetic rats. The purpose of this research was to investigate the novel effects of ASC + G-90 on wound healing by using the synchrotron radiation Fourier transform infrared (SR-FTIR) microspectroscopy. The results showed that oxidative stress and lipids peroxidation were least pronounced in treated skin with ASC + G-90 (T) compared with treated skin with panthenol-D (PC) and the skin without any treatment (NC). The collagen formation was notably observed in the dermis of treated group with ASC + G-90. These findings clearly confirmed the effectiveness of the treatment in skin repair.