Objective: The overweight-related health problems among adolescents are obvious. Resistance training is recognized as a safe and efficacious exercise modality to have health-promoting effects in overweight adolescents. This study aimed to assess the efficacy of circuit resistance training (CRT) in improving inflammatory status, insulin resistance and body composition in overweight male adolescents. Materials and Methods: Twenty overweight adolescent boys (aged: 18.5 (±1), weight: 81.1 (±4.5), body mass index: 27.7 (±0.7)) completed this study. The participants were randomly and equally divided into two groups of control (CG; n=10) and circuit resistance training (CRT; n=10). The CG did their daily routine activities and the CRT group performed its training protocol 3 days a week for 6 weeks. Body composition components and serum variables were measured a day before and after the study. Insulin resistance index was measured by HOMA-IR. Results: The subjects in the CG showed significantly increased changes compared with pre-training values. Moreover, significant changes were found fort the changes of BW (P-value= 0.005), BMI (P-value= 0.001) and BF% (P-value= 0.003) between groups. Conclusion: This study suggested that although six weeks of CRT failed to induce meaningful anti-inflammatory cytokine responses, and to improve body composition and HOMA-IR in overweight adolescent boys, but had protective effects on inflammatory status, HOMA-IR and body composition and prevented them from being deteriorated.
