Background: Volleyball involves intermittent activities closely linked to explosive power and muscular strength. Utilizing the ergogenic supplement beta-alanine can positively influence the balance between anabolic and catabolic factors, potentially enhancing the benefits of sports activities. Objectives: This study aimed to examine the effect of 4 weeks of beta-alanine supplementation on serum myokine levels, as well as aerobic and anaerobic power in elite volleyball players aged 22 - 28 years. Methods: In this quasi-experimental study, 22 male volleyball players from the Division 1 Volleyball League, aged between 22 and 28, were selected and randomly divided into two groups of 11: A supplement group and a control group. The supplement group received 6.4 g/day of beta-alanine (in 8 doses of 800 mg) for 4 weeks. The ANCOVA test was used for data analysis, with a significance level set at P ≤ 0.05. Results: Beta-alanine supplementation significantly increased serum myokine levels (interleukin-15, myonectin, and irisin) compared to the control group (P < 0.05). Additionally, 4 weeks of beta-alanine supplementation was associated with a significant increase in measures of aerobic and anaerobic power (Bruce and Wingate tests) compared to the control group (P < 0.05). Conclusions: Supplementation with Beta-Alanine led to improved performance (aerobic and anaerobic power) by increasing anabolic responses (irisin) and indicators of muscle hypertrophy (IL-15 and myonectin) in elite volleyball players.
