The increasing concern for the environment has led modern academic and industrial chemists to develop chemical processes with maximize yields and minimize cost while using non-toxic reagents and solvents. Multi-component reactions (MCRs) constitute such processes that combine economic aspects with the environmental ones and are powerful tools for the construction of novel and structurally complex molecules in a singlepot reaction. This ensures high atom economy, good yields and low costs, in short reaction times, minimization of waste, labor, energy, and avoidance of tedious purification processes
