Indoline-2,3-dione or indole-1H- 2,3-dione commonly known as isatin, is a well-known natural product found in plants [1]. Isatin and its derivatives may be the most useful starting materials or precursor in the synthesis of a wide number of spirocyclic oxindoles [2-3]. Due to its simple process, easy operation, efficiency and high atomic economy, the reaction base on isatin and its derivatives have become and efficient method for the synthesis of various product in recent years [4-5].
