The pyrrolidine ring is found in large compounds demonstrating a significant range of biological activities. Review of literature has shown that pyrrolidines are well known for their remarkable biological properties such as anticonvulsant, anti-HIV-1, antitumor, ketoamide-based cathepsin K inhibitors, antimicrobial, etc. Multicomponent reactions (MCRs) are useful tools for the efficient synthesis of heterocyclic compounds due to their environmentally friendliness, atomic economy, and green specifications. These reactions proceed through one-pot reactions to form complex heterocyclic structures. Biocatalyst is one of the most powerful tools in both organic and bioorganic synthesis because of its good selectivity, high efficiency, and great environmental tolerability. As a result of these observations and in continuation of our previous works on the synthesis of novel heterocyclic compounds 6, we would like to report the efficient and straightforward protocol for the diastereoselective synthesis of new pharmaceutically relevant 2,5-dioxopyrrolidines using Fe3O4 NPs@ lipase as heterogeneous reusable nanobiocatalyst (NBC), via three-component fashion.
