Isatin has been known for about 150 years and has been recently found, like oxindole and endogenous polyfunctional heterocyclic compounds, to exhibit biological activity in mammals.1 Isatin also is a synthetically versatile substrate that can be used to prepare a large variety of heterocyclic compounds, such as indoles and quinolones, and as a raw material for drug synthesis.2 In continuation of our previous works for the synthesis of novel heterocyclic compounds,3,4 we report herein an efficient approach for the preparation of novel isatin-based conjugates with 1,3-dicarbonyl compounds is described by one-pot reaction of isatin derivatives, 1,3-dicarbonyl compounds, and phenacylbromide in the presence oftriphenylphosphine and sodiumhydrogencarbonate in acetonitrile at reflux (Scheme 1). The target compounds were obtained in excellent yields. The structure of products was confirmed by IR, 1H and 13C NMR spectroscopy and mass spectrometry.
