Aluminum is considered an essential element endowed with toxicity potentials in human and animal. Thus, intoxication withaluminum can lead to oxidative stress, which is associated withoxidative damage to various macromolecules. Moreover, antiox-idants from natural sources can play an important role in human health. Accordingly, the purpose of this study was to investigate theprotective effect ofRosadamascenaextract against aluminum-induced oxidative stress. In this study, 60 male rats were randomlydivided into six groups and then they were given daily aluminum chloride andRosadamascenaextract. After 8 weeks of treatment,the levels of total antioxidant and malondialdehyde, as well as antioxidant enzymes including catalase, glutathione S-transferase,and myeloperoxidase, were measured in all experimental groups in this study. A significant increase was found in the totalantioxidant level in the rats treated with aluminum,Rosadamascenaextract, and aluminum plusRosadamascenaextract comparedwith those in the control group. Also, malondialdehyde levels were not significantly different in allthe studied groups. GlutathioneS-transferase activity levels in rats receiving theRosadamascenaextract as well as rats taking aluminum withRosadamascenaextract increased significantly compared with the ones in the control group. Catalase activity in the aluminum-treated group alsoincreased significantly compared with the rates in the control group (31.34 ± 4.50 U/gHb vs. 14.04 ± 6.17 U/gHb,p= 0.014).Furthermore, myeloperoxidase activity in the aluminum-treated group increased significantly compared with the control group(49.47 ± 5.12 U/L vs. 25.28 ± 2.18 U/L,p< 0.001). TheRosadamascenaextract could improve antioxidant capacity and reduceoxidative conditions in rats receiving aluminum chloride as evidenced by assays of the ferric reducing ability of plasma and activityof antioxidant enzymes. According to the findings of this study, it can be concluded that theRosadamascenaextract with it
