The advent of fuzzy sets, and consequently fuzzy graphs, has solved many problems in ambiguous and uncertain contexts. It is interesting and necessary to study the Wiener index in a cubic fuzzy graph that employs both fuzzy membership and interval-valued fuzzy membership at the same time. In this paper, theWiener index in a cubic fuzzy graph is introduced as a cubic fuzzy number and some related results are described. The comparison between connectivity index and Wiener index, changes in Wiener index through deleting a node or an edge, and determining the Wiener index in some specific cubic fuzzy graphs have been the other topics studied in this research. In addition, the Wiener index is determined by mentioning concepts of the saturated cubic fuzzy cycle. In this review, theWiener index is shown as a combination of classical and interval numbers. The results indicate that when some vertices are removed, theWiener index may change. However, this change will not be exclusively related to both values. Finally, an application of the Wiener index is presented in the study of the properties of some monomer molecules