In the present paper, the heat transfer of pulsatile flow in ribbed tube was investigated numerically by considering the effect of thermal inertia of solid wall thickness. To this purpose, the CVFV technique with collocated grids arrangement was adopted to discretize momentum and energy equations. In order to avoid checker-board of pressure field in numerical simulation, Chow and Rhie interpolation scheme was employed. The wellestablished SIMPLE (Semi-Implicit Method for Pressure Linked Equations) method was utilized to handle velocity and pressure coupling in the momentum equation. Stone’s Strongly Implicit Procedure (SIP) was used to solve the set of individual linear algebraic equations. Womersley number, Reynolds number, velocity amplitude, and wall thickness ratio are four essential parameters that influence heat transfer and Nusselt number in pulsatile flow in a ribbed tube. It was deduced by varying Womersley number Nu does not change. Nu enhances almost 19% by augmentation of wall thickness ratio from 0.125 to 1. It was shown by increasing velocity amplitude from 0.1 to 0.8; Nu reduces almost 4.7%.