Abstract Abundance of cellar springs, ethnic and religious pluralism and exclusive status on one hand, political- economic crispy, cultural clashes and confluence of regional and trans-regional powers on the other hand have identified middle east as an endless region in the world. In other words, transcendence of power politics, utilitarianist and interest-oriented calculations has shown middle east as an area of diversed admixture. In this situation, based upon interest-oriented and national rationality, regional and transregional powers are trying to design the security geometry of the middle east subsystem. Indeed, the presence of trans-regional actors and regional powers attempting to map the region’s security has transformed the middle east as a pole of world’s security- political exchanges.This paper is trying to probe the security approaches of Iran, USA and EU as regional and trans-regional actors toward middle east.