Background: The sperm dysfunction is one of the major causes of men infertility caused by reactive oxygen species (ROSs). These ROSs led to lipid peroxidation (LPO) and the establishment of firm peroxidation products like malondialdehyde (MDA) in seminal and blood plasma. The purpose of this study is association two biomarkers of oxidative stress; total antioxidant capacity (TAC) and MDA with qualityquantity factors in teratospermic men. Methods: Sixty blood and seminal samples including 30 normal samples, as a control groups and 30 teratospermic men samples, as a case groups, were collected from the Fatemezahra IVF centre (Babol, Iran). Semen was analyzed on the basis of World Health Organization, WHO (1999). Seminal and blood plasma TAC and MDA levels in all samples were measured by TBARs and FRAP methods, respectively. Result: Our results showed that TAC level in seminal and blood plasma of normospermic men was significantly higher than teratospermic men and had positive correlation with sperm count, motility and morphology. In contrast seminal and blood plasma MDA levels in normospermic men were significantly lower than in teratospermic men and had negative correlation with sperm count, motility and morphology. Conclusion: Thus, it seems that strengthening the antioxidant capacity of idiopathic infertile male may prevent the development of teratospermic malfunction.
