Cigarette smoke includes number of substances that has negative effects on male reproductive system and cause to male infertility. In this research we investigated the effect of cigarette smoking on sperm parameters both before and after swim-up. Semen sample provided from fertile smoker (n=25), fertile nonsmoker (n=21), infertile smoker (n=23) and infertile nonsmoker men (n=32). Semen analysis was performed manually according to the world health organization (WHO) standards guidelines. Our research showed that sperm parameters quality in smoker men was approximately lower than nonsmoker men. As well as our research showed that cigarette smoking has dose dependent effect on sperm parameters, but this effect was not significant. Therefore it appears that Cigarette smoking is associated with reduced sperm quality and the risk of idiopathic male infertility in smoker men.
