Introduction:Breast cancer has the highest incidence rate in women in the world. telomerase is the most common tumorassociated antigen (taa) and its activity increased in more than 90% of cancers, thus, its targeting can be used as a cancer control. Methods: In this study as a continuing in vitro studies, we re-analyzed htert selected peptides against mice MHC with iedband epimhc database. about 5 × 105 mouse breast cancer 4t1 cells was washed and suspended in 100 μl normalsaline and s.c injected to mammary fat pat of balb/c mice and then start to tumor measurement 2 times a week.about 100 ug klh conjugated peptides accompany incomplete freund′s adjuvant were injected s.c in days 10th and 20th after cancer cells inoculation. Results:The analysis of peptides shown they are can binding to mice mhc i and ii respectively but score of them is significantly lower than their interaction with human HLA. Conclusion:The results were shown contemporary mhc restricted peptide as a vaccine, can inhibit tumor growth and also increase overall survival of vaccinated mice compare untreated group.
