Introduction: The effect of environmental lead (Pb) on the male reproductive system has been a major area of concern for several years. The current study was carried out to evaluate the protective effect of curcumin(CCM) and moderate treadmill running on the reproductive system during exposed to lead acetate (Pb). Material and Methods: 50 male Wistar rats were divided into five groups (10 rats/group): 1)sham-operated, 2)Pb, 3)exercise + Pb, 4)CCM + Pb, and 5)exercise + CCM + Pb. The 2 to 5 groups were exposed to lead acetate (20 mg/kg). In addition, the 4 and 5 groups received CCM solution (30mg/kg), while the 1 group received ethyl oleate, intra peritoneally. The rats in the training groups performed treadmill running consisting of 15 to 22 m/min for 25 to 64 min, 5 times a week for 8 weeks. Motility and morphological profile of sperm, the testis and epididymal MDA and the reproductive hormone were assessed by standards methods. Results: there are no significant differences were found between reproductive hormones concentration in all groups. However, Compared with other groups, mean values of testis and epididymis lipid peroxidation was higher in Pb group but not significant. Moreover, lead administration was corrupted motility and morphology of sperm in Pb group, but intervention of moderate treadmill running and CCM supplement have an ameliorating effect on this parameters. Discussion and Conclusions: The results of this study shows that regular moderate treadmill running and using curcumin supplement are suitable guideline to inhibit the negative effects of Environmental pollution on reproductive system.
