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Hamed Salimi-Kenari

Hamed Salimi-Kenari

Academic rank: Assistant Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Technology and Engineering
Address:
Phone: 01135305105

Research

Title
Fabrication and characterization of dextran/nanocrystalline β-tricalcium phosphate nanocomposite hydrogel scaffolds
Type
JournalPaper
Keywords
Design of bioactive three-dimensional scaffolds to support bone tissue repair and regeneration become a key area of research in tissue engineering. Herein, porous hybrid hydrogels composed of dextran incorporatedwith nanocrystalline β-tricalciumphosphate (β-TCP) particleswere tailor made as scaffolds for bone tissue engineering. β- TCP was successfully introduced within the dextran networks crosslinked through intermolecular ionic interactions and hydrogen bonding confirmed by FTIR spectroscopy. The effect of β-TCP content on equilibrium water uptake and swelling kinetics of composite hydrogelswas investigated. Itwas found that the homogeneous distribution of β-TCP nanoparticles through the hydrogelmatrix contributes to higher porosity and swelling capacity. In depth swelling measurements revealed that while in the early stage of swelling, water diffusion follows the Fick's law, for longer time swelling behavior of hydrogels undergo the second order kinetics. XRDmeasurements represente
Year
2020
Journal International Journal of Biological Macromolecules
DOI
Researchers Rahil Ghaffari ، Hamed Salimi-Kenari ، Farahnaz Fahimipour ، Sayed Mahmood Rabiee ، Hassan Adeli ، Erfan Dashtimoghadam

Abstract

Design of bioactive three-dimensional scaffolds to support bone tissue repair and regeneration become a key area of research in tissue engineering. Herein, porous hybrid hydrogels composed of dextran incorporatedwith nanocrystalline β-tricalciumphosphate (β-TCP) particleswere tailor made as scaffolds for bone tissue engineering. β- TCP was successfully introduced within the dextran networks crosslinked through intermolecular ionic interactions and hydrogen bonding confirmed by FTIR spectroscopy. The effect of β-TCP content on equilibrium water uptake and swelling kinetics of composite hydrogelswas investigated. Itwas found that the homogeneous distribution of β-TCP nanoparticles through the hydrogelmatrix contributes to higher porosity and swelling capacity. In depth swelling measurements revealed that while in the early stage of swelling, water diffusion follows the Fick's law, for longer time swelling behavior of hydrogels undergo the second order kinetics. XRDmeasurements represented the formation of apatite layer on the surface of nanocomposite hydrogels after immersion in the SBF solution, which implies their bioactivity. Cell culture assays confirmed biocompatibility of the developed hybrid hydrogels in vitro. The obtained results converge to offer dextran/β-TCP nanocomposite hydrogels as promising scaffolds for bone regeneration applications.