1403/01/10
ولی اله دبیدی روشن

ولی اله دبیدی روشن

مرتبه علمی: استاد
ارکید: 0000-0002-2202-7349
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده تربیت بدنی و علوم ورزشی
نشانی:
تلفن: 011-35302201

مشخصات پژوهش

عنوان
Taurine supplementation has antiatherogenic and anti-inflammatory effects before and after incremental exercise in heart failure
نوع پژوهش
JournalPaper
کلیدواژه‌ها
anti-atherogenic; anti-inflammatory; exercise; heart failure; taurine
سال
2017
مجله Therapeutic Advances in Cardiovascular Disease
شناسه DOI
پژوهشگران Mehdi Ahmadian ، Valiollah Dabidi Roshan ، elahe aslani ، Stephen R Stannard

چکیده

The purpose of this study was to examine the anti-atherogenic and anti-inflammatory effect of supplemental taurine prior to and following incremental exercise in patients with heart failure (HF). METHODS: Patients with HF and left ventricle ejection fraction less than 50%, and placed in functional class II or III according to the New York Heart Association classification, were randomly assigned to two groups: (1) taurine supplementation; or (2) placebo. The taurine group received oral taurine (500 mg) 3 times a day for 2 weeks, and performed exercise before and after the supplementation period. The placebo group followed the same protocol, but with a starch supplement (500 mg) rather than taurine. The incremental multilevel treadmill test was done using a modified Bruce protocol. RESULTS: Our results indicate that inflammatory indices [C-reactive protein (CRP), platelets] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05) whereas these indices increased in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation in the placebo group ( p < 0.05). Our results also show that atherogenic indices [Castelli's Risk Index-I (CRI-I), Castelli's Risk Index-II (CRI-II) and Atherogenic Coefficient (AC)] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05). No such changes were noted in the placebo group ( p > 0.05). CONCLUSIONS: our results suggest that 2 weeks of oral taurine supplementation increases the taurine levels and has anti-atherogenic and anti-inflammatory effects prior to and following incremental exercise in HF patients.