11 بهمن 1401
اميد جزايري

امید جزایری

مرتبه علمی: استادیار
نشانی:
تحصیلات: دکترای تخصصی / ژنتیک
تلفن: 011-35302450
دانشکده: دانشکده علوم پایه

مشخصات پژوهش

عنوان A male Down syndrome with two normal boys: Cytogenetic, paternity and andrological investigations
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
amniotic fluid karyotype, cytogenetics, Down syndrome, fertility, paternity
مجله ANDROLOGIA
شناسه DOI https://doi.org/10.1111/and.13521
پژوهشگران امید جزایری (نفر اول) ، نسیم گرجی زاده (نفر دوم)

چکیده

Down syndrome is the most common autosomal chromosome anomaly with several medical abnormalities and intellectual disability, occurring in about of 1:1,000 to 1:1,100 infants. Many pregnancies in women with Down syndrome produce children both with normal and with trisomy 21, whereas males are infertile. However, Down syndrome males are not always infertile and this is not global. Here we reported a 36-year-old man with proved nonmosaic trisomy 21 fathered two normal boys. Paternity analysis using 26 microsatellite loci confirmed that Down syndrome male is the biological father of his two normal boys. Serum LH, FSH, testosterone and 17-OH progesterone were all in the normal range in this father with Down syndrome. To the best of our knowledge, this is the second report of one man with Down syndrome who has two normal children in the world. The current study not only supports the rare evidence of the fertility of males with Down syndrome but also highlights the caution in advising people responsible for the care of adults with this condition about possible fertility and transmission of sexual diseases as well