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Majid Tafrihi

Majid Tafrihi

Academic rank: Assistant Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Science
Address: Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran, Postal code: 4741695447
Phone: 01135305252

Research

Title
MiRNAs: Biology, Biogenesis, Their Web-based Tools, and Databases
Type
JournalPaper
Keywords
Biogenesis, databases, miRNA, mRNA target, web-based tools
Year
2019
Journal MicroRNA (Shāriqah, United Arab Emirates)
DOI
Researchers Majid Tafrihi ، Elham Hashemi Nasab

Abstract

Introduction: MicroRNAs (miRNAs), which are evolutionarily conserved, and endogenous non-coding RNAs, participate in the post-transcriptional regulation of eukaryotic genes. The biogenesis of miRNAs occurs in the nucleus. Then, in the cytoplasm, they are assembled along with some proteins in a ribonucleoprotein complex called RISC. miRNA component of the RISC complex binds to the complementary sequence of mRNA target depending on the degree of complementarity, and leads to mRNA degradation and/or inhibition of protein synthesis. miRNAs have been found in eukaryotes and some viruses play a role in development, metabolism, cell proliferation, growth, differentiation, and death. Objective: A large number of miRNAs and their targets were identified by different experimental techniques and computational approaches. The principal aim of this paper is to gather information about some miRNA databases and web-based tools for better and quicker access to relevant data. Results: Accordingly, in this paper, we collected and introduced miRNA databases and some webbased tools that have been developed by various research groups. We have categorized them into different classes including databases for viral miRNAs, and plant miRNAs; miRNAs in human beings, mice and other vertebrates; miRNAs related to human diseases, and target prediction; and miRNA expression. Also, we have presented relevant statistical information about these databases.