Melanomas are malignant skin tumors originate from the transformation of the melanocytes. Teucrium genus belongs to the Ajugoideae subfamily and the Lamiaceae family, which its species are used to treat a diversity of diseases including diabetes, inflammation, hyperlipidemia, rheumatism and cancer. Teucrium persicum is an endemic plant of Iran, which is used in traditional medicine for relieve headache and abdominal pains. The purpose of this study is to investigate the cytotoxicity and antioxidant effects of methanolic extract of T. persicum on A-375 cells. In this study, the efficacy of different concentrations of T. persicum plant extract on A-375 and HEK-293 cell lines was evaluated by using MTT assay and the antioxidant effect of T. persicum extract was studied using the total phenolic content assay. The results of MTT assay showed that T. persicum extract significantly reduced viability of A-375 cells (IC50 = 36.13 and 13μg/ml for 24 and 48 hours respectively) and HEK-293 cells (IC50 = 49.94μg/ml for 48 hours). In addition, . These results suggest that T. persicum is a plant with very high anticancer and antioxidant activity.
