1403/01/10

فرشته میر محمدرضایی

مرتبه علمی: استادیار
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده علوم پایه
نشانی: گروه زیست شناسی ،دانشکده علوم پایه، دانشگاه مازندران
تلفن: 35302450

مشخصات پژوهش

عنوان
Current Chemical Genomics and Translational Medicine
نوع پژوهش
JournalPaper
کلیدواژه‌ها
Low-density lipoprotein cholesterol, LDL-C, IL-17A, Atherosclerosis, Inflammation
سال
2018
مجله Current Chemical Genomics and Translational Medicine
شناسه DOI
پژوهشگران azam roohi ، Mina Tabrizi ، Fereshteh Mir Mohammadrezaei ، Mehdi Yaseri ، Behrous Nikbin

چکیده

Background: Hypercholesterolemia is a modifiable risk factor in atherosclerosis with a complex association with inflammation. Objective: In the present study, the association between low-density lipoprotein cholesterol (LDL-C) and interleukin 17A (IL-17A), as an inflammatory cytokine, was investigated. In addition to IL-17A, serum levels of interleukin 23 (IL-23) and transforming growth factor β (TGF-β), as effective cytokines in T helper 17 cell (Th17) development, were also determined. Method: Cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA) in healthy subjects with LDL-C<130 versus LDL-C=>130 mg/dL. Results: Although IL-17A is an inflammatory cytokine and a positive association between its levels and LDL-C is expected, the data obtained in this study provide support for a reverse association (p<0.05). Conclusion: Inflammation plays a major role in atherosclerosis development; however, various inflammatory components involved in atherosclerosis assert their own unique association with hypercholesterolemia.