20 بهمن 1401
علي طراوتي

علی طراوتی

مرتبه علمی: استادیار
نشانی: بابلسر، دانشگاه مازندران، دانشکده علوم پایه، گروه زیست شناسی سلولی و مولکولی، کدپستی 95447-47416
تحصیلات: دکترای تخصصی / بیوشیمی
تلفن: 35305250
دانشکده: دانشکده علوم پایه

مشخصات پژوهش

عنوان
Association between Estrogen Receptor-Alpha Gene XbaI (A/G) polymorphisms and Preeclampsia Risk: A meta-analysis
نوع پژوهش مقاله ارائه شده
کلیدواژه‌ها
Pre-eclampsia, ESR1, XbaI (A/G), Meta-analysis
پژوهشگران علی طراوتی (نفر اول) ، سیده طاهره میرصالحی (نفر دوم)

چکیده

Objectives: Estrogen receptor α (ESR1), a member of the nuclear hormone receptor superfamily, functions as a ligand-activated transcription factor. This receptor play a pivotal role in systemic circulation maintenance during pregnancy. ESR1 XbaI (A/G) polymorphism was proposed to be associated with the risk of fetal growth abnormality in pre-eclampsia. Methods: A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals were calculated under dominant, recessive, co-dominant, and allelic models. Results: This meta-analysis included 4 eligible studies consisting 612 cases and 619 controls. The ORs for the XbaI (A/G) polymorphism and pre-eclampsia were not indicative of any association under several genetic models including dominant model (GG+AG vs. AA: OR = 1.036 [95%CI: 0.793–1.354]; p = 0.795), recessive model (GG vs. AG+AA: OR =1.352 [95%CI: 0.920–1.986]; p = 0.125), co-dominant model (GG vs. AA: OR = 1.267 [95%CI: 0.833–1.927]; p = 0.269), and allelic model (G vs. A: OR = 1.090 [95%CI: 0.919–1.293]; p = 0.320). Conclusions: In order to better understand the potential etiology for pre-eclampsia in human, large well-designed studies with more participants are needed to perform the association of this polymorphism with pre-eclampsia among different ethnic population in future. It also will be necessary to perform research studies that included combined genetic factors, haplotype analysis and other risk factors in different ethnic population.