Background. Moyenctin, is a new identified myokine and belongs to the CTRPs family which plays role in lipid and glucose metabolism. There is limited information available regarding the effects of exercise training on serum myonectin levels. Objectives. he aim of this study was to investigate the effects of sucrose solution intake and resistance training (RT) with two different volumes on serum myonectin levels and HOMA-IR in rats. Methods. Forty-eight male Wistar rats (10-12 weeks old) were randomly divided into six groups; Control (C), Low volume RT (L), High Volume RT (H), Sucrose Control (SC), Sucrose Low volume RT (SL) and Sucrose High volume RT (SH). The RT groups were subjected to a resistance training program with the use of a ladder (3 days/week, for 8 weeks). Body weight and serum levels of myonectin, insulin, glucose, and HOMA-IR were measured. Results. The results two way ANOVA showed that interaction between RT and sucrose solution significantly increased serum levels of insulin (P=0.007) and HOMAL-IR (P=0.002). Consumption of sucrose solution, significantly reduced serum myonectin (P=0.0001) and increased serum glucose, insulin and HOMA-IR (P=0.0001). Also RT significantly reduced serum myonectin, insulin and HOMA-IR (P=0.0001). No correlation was found between serum myonectin and insulin resistance in groups fed with normal foods (P=0.456), but in the groups fed with sucrose solution there was positive and significant correlation (P=0.0001). Conclusion. This data indicated that resistance training regardless of volume of training can reduce serum myonectin levels as well as insulin resistance in rats fed with sucrose solution or normal diet groups.
