1403/01/09
عبدالعلی موحدی نیا

عبدالعلی موحدی نیا

مرتبه علمی: استاد
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده علوم دریایی و محیطی
نشانی:
تلفن: 011-35305113

مشخصات پژوهش

عنوان
Detection of benzo[a]pyrene-induced immunotoxicity in orange spotted grouper (Epinephelus coioides)
نوع پژوهش
JournalPaper
کلیدواژه‌ها
polycyclic aromatic hydrocarbon; innate immunity; acquired immunity; orange spotted grouper
سال
2014
مجله ENVIRONMENTAL TOXICOLOGY
شناسه DOI
پژوهشگران Maryam Khanian ، Negin Salamat ، Alireza Safahieh ، Abdolali Movahedinia

چکیده

This study aimed to investigate the effects of benzo[a]pyrene (BaP) on immune status of orange spotted grouper (Epinephelus coioides). Fish were injected with 2, 20 and 35 mg/kg-bw of BaP and were kept under laboratory conditions for 14 days. Blood samples were taken at days 1, 4, 7, and 14 and changes in total WBC and RBC, phagocytosis, lysozyme activity, lysosomal membrane stability, immunoglobulin M (IgM) level and antibacterial activity were evaluated. Also BaP bioaccumulation in fish muscle was measured. BaP concentration in the muscle of treated fish reached a maximum level after 4 days (P < 0.05). Exposure of fish to BaP resulted in a significant decrease of total RBC and WBC, lysozyme activity, lysosomal membrane stability, IgM level and antibacterial activity after 4 days and phagocytosis after 7 days of the experiment (P < 0.05). Totally, the results revealed BaP ability to suppress the fish immune function.