1403/01/09
اباصلت حسین زاده کلاگر

اباصلت حسین زاده کلاگر

مرتبه علمی: استاد
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده علوم پایه
نشانی:
تلفن: 01135302452

مشخصات پژوهش

عنوان
The AhRR-c.565C>G transversion may increase total antioxidant capacity levels of the seminal plasma in infertile men
نوع پژوهش
JournalPaper
کلیدواژه‌ها
Maleinfertility .AhRR-c.565C>G .Antioxidant capacity
سال
2017
مجله ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
شناسه DOI
پژوهشگران Seyed Gholam Ali Jorsarayi ، Azadeh Mohammad Hasani ، Younes Aftabi ، Emadodin Moudi ، Abasalt Hosseinzadeh Colagar

چکیده

The Aryl hydrocarbon receptor (AhR)-repressor (AhRR) is a regulator of the AhR pathway, which plays an important role in xenobiotic and reactive oxygen species (ROS) metabolism. Total antioxidant capacity (TAC) is a major factor in semen quality that protects sperm against ROS stress. Malondialdehyde (MDA) is the indicator of lipid peroxidation damage that is occurred due to ROSs. In this study, we determined and compared the MDA and TAC levels of infertile men’s semen and blood plasma regarding genotype groups of AhRR-c.565C>G transversion. Semen and blood samples of 123 infertile males were collected from the FatemehZahraIVFCentre,Babol,Iran.TACandMDAlevels of seminal and blood plasma were measured by TBARS and FRAP methods, respectively. Cases were genotyped by the PCR-RFLP method. The frequency of c.565C>G genotypes was determined as CC (34.14%), CG (55.28%) and GG (10.58%). Mean levels of TAC μm/L and MDA nmol/mL in semenplasmaofCC,CGandGGgroupswere(1365.7,1.28), (1542.8, 1.51) and (1860.2, 0.82), respectively. Also, mean levels of TAC μm/L and MDA nmol/mL in blood plasma samples in CC, CG and GG genotypes were (806.14, 1.168), (727.1, 1.006) and (635.7, 0.83), respectively. Comparisonofmarkerlevelsbetweengenotypesrevealedthat the TAC level of semen plasma in the GG genotype was significantlyhigherthanitslevelintheCCgroup(p<0.05).Our findings showed that in seminal plasma of infertile men with the GG genotype of AhRR-c.565C>G transversion, the level of total antioxidant capacity is significantly higher in comparison with the CC genotype. Then, the G allele of AhRRc.565C>G transversion may have a role in the increase in antioxidant capacity of seminal plasma.