1403/01/10
اکبر حاجی زاده مقدم

اکبر حاجی زاده مقدم

مرتبه علمی: دانشیار
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده علوم پایه
نشانی:
تلفن: 01135302453

مشخصات پژوهش

عنوان
The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats
نوع پژوهش
JournalPaper
کلیدواژه‌ها
'Aβ1-42' 'Voluntary wheel running' 'Rats'
سال
2013
مجله zahedan journal of research in medical sciences
شناسه DOI
پژوهشگران ziya fallah mohammadi ، Akbar Hajizadeh Moghaddam ، mojtaba ebrahim zade

چکیده

Background: Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan. Materials and Methods: 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal. Results: 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001). Conclusion: voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.