1403/01/10
اکبر حاجی زاده مقدم

اکبر حاجی زاده مقدم

مرتبه علمی: دانشیار
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده علوم پایه
نشانی:
تلفن: 01135302453

مشخصات پژوهش

عنوان
Central administration of GPR55 receptor agonist and antagonist modulates anxietyrelated behaviors in rats
نوع پژوهش
JournalPaper
کلیدواژه‌ها
anxiety, GPR55, intracerebroventricular administration, rats
سال
2015
مجله FUNDAMENTAL & CLINICAL PHARMACOLOGY
شناسه DOI
پژوهشگران Abbasali Rahimi ، Akbar Hajizadeh Moghaddam ، ali roohbakhsh

چکیده

G-protein-coupled receptor 55 (GPR55) has been proposed as an atypical cannabinoid receptor, which is activated by lysophosphatidylinositols and some synthetic or endogenous cannabinoid molecules. The exact role of GPR55 receptors in the central nervous system especially in anxiety needs to be evaluated. In this study, the effects of intracerebroventricular (i.c.v.) administration of agonist and antagonist of GPR55 receptor on anxiety-related behaviors in rats were investigated. Here, O-1602 (GPR55 agonist) at the doses of 0.2, 1, and 5 lg/rat increased %OAT and %OAE but not the locomotor activity, showing an anxiolytic response, whereas i.c.v. injection of ML193 (GPR55 antagonist) at the doses of 0.1 and 1 lg/rat increased anxiety-like behaviors while causing locomotor impairment. The antagonistic effect of ML193 on the anxiolytic-like effect of O-1602 was also evaluated. The results showed that ML193 decreased the anxiolytic-like effect of O-1602. Based on these results, it may be concluded that central GPR55 may have a role in modulation of anxiety-like behaviors in rats. Further experiments are needed to elucidate the exact role of these receptors in anxiety.