2024 : 4 : 29
Ali Bahari

Ali Bahari

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Science
Address:
Phone: 9112537702

Research

Title
Preparation and Characterization of Magnetite–Chitosan Nanoparticles and Evaluation of Their Cytotoxicity Effects on MCF7 and Fibroblast Cells
Type
JournalPaper
Keywords
Fe3O4–chitosan nanoparticles · Superparamagnetic · Core–shell structure · Cytotoxicity
Year
2017
Journal Journal of Superconductivity and Novel Magnetism
DOI
Researchers Shida Lotfi ، Fahimeh Qhaderi ، Ali Bahari ، asaoleiman Mahjoub

Abstract

Nowadays, magnetic nanoparticles play a key role in drug treatment. However, if they are uncoated, they might aggregate and cause embolism in drug delivery. To avoid this, they are generally coated with polymers. In this investigation, magnetic nanoparticles (MNPs) were coated with chitosan through in situ co-precipitation process and their properties in addition to their cytotoxicity in MCF7 and fibroblast cells were analyzed. The results showed MNPs–chitosan nanoparticles would contain an average mean diameter of 32 nm and a saturation magnetization (MS) value of 38.87 emu/g. To characterize the synthesized nanoparticles in terms of structural, morphological and magnetic properties, Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA) and vibrating sample magnetometry (VSM) studies were used. Toxicity test was also done to investigate whether their presence would cause any toxicity in the body; in addition, antibacterial assay was done to analyze if nanoparticles could be used as an antimicrobial agent.