مشخصات پژوهش

صفحه نخست /The TNF-a, P53 protein ...
عنوان The TNF-a, P53 protein response and lung respiratory changes related to exercise, chronic hypoxia and Adiantum capillus-veneris supplementation
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها apoptosis, lung, interval training, respiratory surface
چکیده Introduction: Evidence suggests that hypoxia and high-intensity exercise training can increase apoptosis of lung cells and Adiantum capillus-veneris (Ac-v) extract can have anti-apoptotic effects. Thus, the aim of the present study was to investigate the effect of chronic hypoxia and the (Ac-v) extraction as a supplement on TNF-a and P53 protein expression as well as the respiratory surface. Material and methods: 24 healthy Wistar rats (age = 4 weeks, weight = 72 = 9 gr) were trained using interval training for 6 weeks followed by a 3-week stay in hypoxia conditions. Half of the hypoxia samples received 500 ml/gr/per body weight daily (Ac-v) within 3 weeks of hypoxia. At the end, the lung tissue was removed for histological and immunohistological analysis. Results: After 3 weeks of hypoxia exposure following 6 weeks of exercise, expression of P53 and TNF-a increased and the respiratory surface decreased (p ≤ 0.05). After 3 weeks of taking the Ac-v extract during hypoxia exposure, reduced P53 and TNF-a expression and the increased respiratory surface were observed (p ≤ 0.05). Conclusions: Chronic hypoxia may be considered as a strong stimulus leading to the expression of proteins involved in apoptosis and tissue disruption. However, our findings suggest that the antioxidative properties of Ac-v extract could decrease the destructive structural and molecular events that happen along with hypoxia exposure or intense exercise training.
پژوهشگران حسن زهل (نفر ششم به بعد)، آنتونی هاکنی (نفر ششم به بعد)، عبدالرئوف بن عبدالرحمان (نفر ششم به بعد)، فاطما راحیبی (نفر ششم به بعد)، ایوب سعیدی (نفر ششم به بعد)، سیدمحسن افخمی (نفر پنجم)، غلامرضا حمیدیان (نفر چهارم)، شادمهر میردار (نفر سوم)، سیمین ریاحی (نفر دوم)، مهدی یادگاری (نفر اول)